TSKgel® UP-SW3000 UHPLC COLUMNS

TSKgel UP-SW3000 columns packed with 2 μm silica based particles are the latest addition to the popular TSKgel SW series, the gold standard for QC analysis of antibody therapeutics. The new silica-based UHPLC columns are based on the proven proprietary surface technology of the renowned TSKgel SW series and facilitate the transfer of existing HPLC methods to UHPLC systems.

Aqueous size exclusion chromatography (SEC) is the method of choice for the analysis of proteins fragments, monomers, and aggregates under non-denaturing condi- tions. Based on the flow of the sample through a porous stationary phase SEC separates molecules according to their size, or more precisely, their hydrodynamic volume. In aqueous elution systems SEC is also referred to as gel filtration chromatography (GFC). TSKgel G3000SWXL columns have been the industry’s standard for quality control of monoclonals by SEC for decades.

HIGHLIGHTS

• Proven TSKgel SW SEC quality
• Virtual absence of nonspecific interaction
• Easy transfer of existing HPLC methods
• Optimized for mAb quality control